Depression in young people is different from the depression in adults. The symptoms and the responses to antidepressants are also dissimilar to those in adults. David Rosenberg and colleagues at Wayne State University\'s School of Medicine have been peering into the brains of many of 9- to 17-year-old patients suffering from major depression and have discovered that the left side of the prefrontal cortex is clearly larger than the right side. In contrast, in adults, the left prefrontal cortex is often shrunk. As a result, young people are more prone to act on their impulses, including self-destructive ones, than adults are.